{"id":1402,"date":"2018-01-19T09:07:56","date_gmt":"2018-01-19T11:07:56","guid":{"rendered":"https:\/\/academiadepacientes.com.br\/?p=1402"},"modified":"2020-02-27T11:59:46","modified_gmt":"2020-02-27T14:59:46","slug":"riscos-da-vacinacao-em-criancas-com-doencas-raras","status":"publish","type":"post","link":"https:\/\/academiadepacientes.com.br\/?p=1402","title":{"rendered":"Riscos da vacina\u00e7\u00e3o em crian\u00e7as com doen\u00e7as raras"},"content":{"rendered":"<div id=\"__sec1\" class=\"tsec sec headless whole_rhythm\">\n<p><img data-opt-id=79381605  fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-1403\" src=\"https:\/\/mlzfzsux7b5d.i.optimole.com\/w:auto\/h:auto\/q:mauto\/f:best\/https:\/\/academiadepacientes.com.br\/wp-content\/uploads\/2018\/01\/vaccination-1215279_1280.jpg\" alt=\"\" width=\"1280\" height=\"853\" srcset=\"https:\/\/mlzfzsux7b5d.i.optimole.com\/w:1280\/h:853\/q:mauto\/f:best\/https:\/\/academiadepacientes.com.br\/wp-content\/uploads\/2018\/01\/vaccination-1215279_1280.jpg 1280w, https:\/\/mlzfzsux7b5d.i.optimole.com\/w:300\/h:200\/q:mauto\/f:best\/https:\/\/academiadepacientes.com.br\/wp-content\/uploads\/2018\/01\/vaccination-1215279_1280.jpg 300w, https:\/\/mlzfzsux7b5d.i.optimole.com\/w:768\/h:512\/q:mauto\/f:best\/https:\/\/academiadepacientes.com.br\/wp-content\/uploads\/2018\/01\/vaccination-1215279_1280.jpg 768w, https:\/\/mlzfzsux7b5d.i.optimole.com\/w:1024\/h:682\/q:mauto\/f:best\/https:\/\/academiadepacientes.com.br\/wp-content\/uploads\/2018\/01\/vaccination-1215279_1280.jpg 1024w, https:\/\/mlzfzsux7b5d.i.optimole.com\/w:1200\/h:800\/q:mauto\/f:best\/https:\/\/academiadepacientes.com.br\/wp-content\/uploads\/2018\/01\/vaccination-1215279_1280.jpg 1200w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p id=\"__p1\" class=\"p p-first-last\" style=\"text-align: justify;\">Doen\u00e7as infecciosas s\u00e3o um grave problema de sa\u00fade p\u00fablica no mundo inteiro, causando in\u00fameras complica\u00e7\u00f5es s\u00e9rias, incluindo dist\u00farbios autoimunes em popula\u00e7\u00f5es n\u00e3o-vacinadas.<\/p>\n<p class=\"p p-first-last\" style=\"text-align: justify;\">As vacina\u00e7\u00f5es representam o mais eficaz m\u00e9todo de prevenir doen\u00e7as infecciosas e a an\u00e1lise de custo-benef\u00edcio de programas de vacina\u00e7\u00e3o j\u00e1 demonstrou a sua utilidade.<\/p>\n<p class=\"p p-first-last\" style=\"text-align: justify;\">Com base nas informa\u00e7\u00f5es da Orphanet, na It\u00e1lia, as doen\u00e7as raras afetam quase 2 milh\u00f5es de pessoas, e 70% delas s\u00e3o crian\u00e7as.<\/p>\n<p class=\"p p-first-last\" style=\"text-align: justify;\">Entre os dist\u00farbios neurodegenerativos, crian\u00e7as com <span style=\"text-decoration: underline;\"><strong>atrofia muscular espinhal<\/strong><\/span> (AME) devem receber imuniza\u00e7\u00f5es de rotina, incluindo vacinas contra influenza e pneumococos; para pacientes pedi\u00e1tricos afetados com a <span style=\"text-decoration: underline;\"><strong>distrofia muscular de Becker<\/strong><\/span>, vacinas contra influenza e pneumococos s\u00e3o indicadas em caso de fraqueza severa dos m\u00fasculos respirat\u00f3rios [<a class=\" bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4707646\/#B1\" aria-expanded=\"false\" aria-haspopup=\"true\">1<\/a>].<\/p>\n<p class=\"p p-first-last\" style=\"text-align: justify;\"><span style=\"text-decoration: underline;\"><strong>Pacientes imunocomprometidos<\/strong><\/span> s\u00e3o um grupo especial com quest\u00f5es muito particulares envolvendo a imuniza\u00e7\u00e3o: em caso de <span style=\"text-decoration: underline;\"><strong>imunodefici\u00eancia de c\u00e9lulas B e T<\/strong><\/span>, vacinas com v\u00edrus vivos atenuados (poliomielite oral, caxumba, sarampo, rub\u00e9ola, BCG e varicela zoster) devem ser evitadas, dado o risco importante de doen\u00e7as induzidas pela vacina [<a class=\" bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4707646\/#B1\" aria-expanded=\"false\" aria-haspopup=\"true\">1<\/a>].<\/p>\n<p class=\"p p-first-last\" style=\"text-align: justify;\"><span style=\"text-decoration: underline;\"><strong>Indiv\u00edduos imunocomprometidos<\/strong><\/span> t\u00eam resposta sub\u00f3tima \u00e0 vacina da hepatite B; desta forma, devem receber uma dose dupla da mesma. A administra\u00e7\u00e3o de vacinas com virus vivos \u00e9 contraindicada em pacientes com <span style=\"text-decoration: underline;\"><strong>agamaglobulinemia<\/strong><\/span>, incluindo a <span style=\"text-decoration: underline;\"><strong>agamaglobulinemia ligada ao X<\/strong><\/span>, <span style=\"text-decoration: underline;\"><strong>s\u00edndrome de hiper IGM<\/strong><\/span> e <span style=\"text-decoration: underline;\"><strong>imunodefici\u00eancia vari\u00e1vel comum<\/strong><\/span> e em pacientes com <span style=\"text-decoration: underline;\"><strong>s\u00edndrome de Wiskott-Aldrich<\/strong><\/span>.<\/p>\n<p class=\"p p-first-last\" style=\"text-align: justify;\">Sujeitos com doen\u00e7as mitocondriais devem seguir o calend\u00e1rio de vacina\u00e7\u00e3o de rotina [<a class=\" bibr popnode\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4707646\/#B1\" aria-expanded=\"false\" aria-haspopup=\"true\">1<\/a>].\u00a0 A vacina\u00e7\u00e3o com vacinas de virus vivos atenuados deve ser evitada em pacientes com <span style=\"text-decoration: underline;\"><strong>doen\u00e7as reumatol\u00f3gicas<\/strong><\/span>\u00a0apenas se eles estiverem recebendo altas doses de medicamentos imunosupressores [<a id=\"__tag_503899940\" class=\" bibr popnode tag_hotlink tag_tooltip\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4707646\/#B2\" aria-expanded=\"false\" aria-haspopup=\"true\">2<\/a>].<\/p>\n<p class=\"p p-first-last\" style=\"text-align: justify;\">A imuniza\u00e7\u00e3o sarampo-caxumba-rub\u00e9ola \u00e9 contraindicada em sujeitos com <span style=\"text-decoration: underline;\"><strong>p\u00farpura autoimune<\/strong><\/span> dado o risco aumentado de trombocitopenia [<a id=\"__tag_503899942\" class=\" bibr popnode tag_hotlink tag_tooltip\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4707646\/#B3\" aria-expanded=\"false\" aria-haspopup=\"true\">3<\/a>].<\/p>\n<p class=\"p p-first-last\" style=\"text-align: justify;\">Men\u00e7\u00e3o especial deve ser feita a <span style=\"text-decoration: underline;\"><strong>beb\u00eas prematuros<\/strong><\/span>. <span style=\"text-decoration: underline;\"><strong>\u00c9 errado<\/strong><\/span> supor que, em prematuros, est\u00edmulos alog\u00eanicos podem ser perigosos, na medida em que estes beb\u00eas s\u00e3o fracos e j\u00e1 estressados por estrat\u00e9gias de ressuscita\u00e7\u00e3o e terapias agressivas. Al\u00e9m disso, eles apresentam deficit de IgG, na medida em que a imunoglobulina cruza a barreira placent\u00e1ria principalmente durante o terceiro trimeste de gravidez.<\/p>\n<p class=\"p p-first-last\" style=\"text-align: justify;\">No entanto, tem sido demonstrado que beb\u00eas prematuros t\u00eam uma resposta imunol\u00f3gica pr\u00f3pria \u00e0 vacina\u00e7\u00e3o recebida no primeiro ano de vida <span style=\"text-decoration: underline;\"><strong>e os efeitos colaterais n\u00e3o s\u00e3o maiores que os observados em beb\u00eas a termo<\/strong><\/span>. Assim, <span style=\"text-decoration: underline;\"><strong>beb\u00eas prematuros devem ser vacinados de acordo com o calend\u00e1rio recomendado para beb\u00eas a termo<\/strong><\/span>, sem corre\u00e7\u00e3o para idade gestacional. Concluindo, <span style=\"text-decoration: underline;\"><strong>sujeitos imunocomprometidos e beb\u00eas prematuros<\/strong><\/span> n\u00e3o t\u00eam uma incid\u00eancia aumentada de rea\u00e7\u00f5es adversas decorrentes da vacina\u00e7\u00e3o, se todas as medidas preventivas e recomenda\u00e7\u00f5es forem adotadas [<a id=\"__tag_503899941\" class=\" bibr popnode tag_hotlink tag_tooltip\" role=\"button\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4707646\/#B4\" aria-expanded=\"false\" aria-haspopup=\"true\">4<\/a>].<span style=\"font-size: 28px; font-weight: 900;\">\u00a0<\/span><\/p>\n<\/div>\n<h4>Refer\u00eancias<\/h4>\n<ol>\n<li>AIFA. Rapporto sulla sorveglianza postmarketing dei vaccini in Italia. 2013. http:\/\/www.agenziafarmaco.gov.it. Accessado em 9 de abril de 2015.<\/li>\n<li>M\u00fcller-Ladner C, M\u00fcller-Ladner U. Vaccination and inflammatory arthritis: overview of current vaccines and recommended uses in rheumatology. Curr Rheumatol Rep. 2013;15:330\u2013336.<\/li>\n<li>Sener AG, Afsar I. Infection and autoimmune disease. Rheumatol Int. 2012;32:3331\u20133338. doi: 10.1007\/s00296-012-2451-z.<\/li>\n<li>Saari Thomas N. Immunization of preterm and low birth weight infants. Pediatrics. 2003;112:193\u2013198. doi: 10.1542\/peds.112.1.193.<\/li>\n<\/ol>\n<h4>Fonte:<\/h4>\n<p style=\"text-align: justify;\">Barberi, Ignazio, Venera Tiralongo, and Lucia Marseglia. \u201cVaccination Risks in Children with Rare Diseases.\u201d <strong>Italian Journal of Pediatrics<\/strong> 41.Suppl 2 (2015): A5. PMC. Web. 19 Jan. 2018.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Doen\u00e7as infecciosas s\u00e3o um grave problema de sa\u00fade p\u00fablica no mundo inteiro, causando in\u00fameras complica\u00e7\u00f5es s\u00e9rias, incluindo dist\u00farbios autoimunes em &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"Riscos da vacina\u00e7\u00e3o em crian\u00e7as com doen\u00e7as raras\" class=\"read-more button\" href=\"https:\/\/academiadepacientes.com.br\/?p=1402#more-1402\" aria-label=\"Read more about Riscos da vacina\u00e7\u00e3o em crian\u00e7as com doen\u00e7as raras\">Saiba mais<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[32],"tags":[83],"class_list":["post-1402","post","type-post","status-publish","format-standard","hentry","category-trocando-em-miudos","tag-vacinacao","infinite-scroll-item"],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"mailpoet_newsletter_max":false},"uagb_author_info":{"display_name":"Cl\u00e1udio Cordovil","author_link":"https:\/\/academiadepacientes.com.br\/?author=2"},"uagb_comment_info":0,"uagb_excerpt":"Doen\u00e7as infecciosas s\u00e3o um grave problema de sa\u00fade p\u00fablica no mundo inteiro, causando in\u00fameras complica\u00e7\u00f5es s\u00e9rias, incluindo dist\u00farbios autoimunes em ... Saiba mais","_links":{"self":[{"href":"https:\/\/academiadepacientes.com.br\/index.php?rest_route=\/wp\/v2\/posts\/1402","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academiadepacientes.com.br\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academiadepacientes.com.br\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academiadepacientes.com.br\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/academiadepacientes.com.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1402"}],"version-history":[{"count":0,"href":"https:\/\/academiadepacientes.com.br\/index.php?rest_route=\/wp\/v2\/posts\/1402\/revisions"}],"wp:attachment":[{"href":"https:\/\/academiadepacientes.com.br\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1402"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academiadepacientes.com.br\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1402"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academiadepacientes.com.br\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}